Dr. Pearce obtained her Ph.D. in 2005 at the University of Pennsylvania in Philadelphia, where she studied the regulation of T cell responses during infection. During her postdoctoral studies at the University of Pennsylvania, she began her research into how cellular metabolic processes govern immune responses to infection and cancer. In 2009, Dr. Pearce launched her independent research career as an Assistant Member at the Trudeau Institute in Saranac Lake, New York. In 2011, she moved to Washington University in St. Louis as an Assistant Professor. In 2015, Dr. Pearce became a Director at the Max Planck Institute for Immunobiology and Epigenetics in Freiburg, Germany. Her research continues to investigate metabolic pathways in immune cells, with a view to targeting these pathways for therapy.